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Ideal Applications

The unique selectivity of the Raptor FluoroPhenyl stationary phase makes it particularly valuable for challenging separations where conventional C18 or Biphenyl columns may not provide sufficient resolution.

Typical application areas include:

  • Pharmaceutical active pharmaceutical ingredients (APIs)
  • Pharmaceutical impurities and degradation products
  • Stability-indicating methods
  • Positional and structural isomer separations
  • Halogenated pharmaceuticals
  • Veterinary drug residue analysis
  • Pesticides and herbicides
  • Environmental contaminants
  • Polycyclic aromatic hydrocarbons (PAHs)
  • Phenolic compounds
  • Flavonoids and natural products
  • Food safety testing
  • Clinical and forensic toxicology
  • LC-MS/MS multi-residue methods

The fluorophenyl chemistry is particularly effective for compounds containing fluorine, chlorine, bromine, or other electron-withdrawing substituents, where additional dipole interactions and aromatic selectivity frequently result in superior chromatographic resolution compared to conventional alkyl phases.

Technical Specifications

Specification Description
Stationary Phase Proprietary FluoroPhenyl bonded phase
Particle Technology Superficially Porous (Core-Shell) Silica
Particle Size 2.7 µm
Pore Size 90 Å
USP Classification L43
Separation Mechanisms Hydrophobic interactions, π-π interactions, dipole interactions, hydrogen bonding, steric (shape) selectivity
Surface Chemistry Fluorinated phenyl ligand bonded to high-purity silica
Recommended pH Range 2.0–8.0
Maximum Operating Pressure Compatible with HPLC and UHPLC systems (instrument dependent)
Mobile Phase Compatibility Water, methanol, acetonitrile, buffered mobile phases, LC-MS compatible solvents
LC-MS Compatibility Excellent using volatile mobile phases
Available Column Dimensions Multiple analytical and UHPLC formats available

Why Choose the Raptor™ FluoroPhenyl 90 Å?

The Restek Raptor FluoroPhenyl 90 Å HPLC column provides a powerful alternative to conventional reversed-phase chemistries by delivering enhanced selectivity for aromatic, halogenated, and structurally related compounds. Its unique fluorophenyl stationary phase allows analysts to achieve improved chromatographic resolution while reducing method development time and minimizing the need for complex mobile phase optimization.

Combined with Restek's advanced core-shell particle technology, the Raptor FluoroPhenyl offers high efficiency, excellent reproducibility, and long column lifetime, making it an ideal solution for pharmaceutical analysis, environmental monitoring, food safety, clinical research, and forensic laboratories.

Available Column Dimensions

The Raptor FluoroPhenyl 90 Å HPLC series is available in multiple column dimensions to support method development, routine analysis, and high-throughput workflows.

  • Particle Size: 2.7 µm
  • Pore Size: 90 Å
  • Internal Diameters: 2.1 mm, 3.0 mm, and 4.6 mm
  • Column Lengths: 30 mm, 50 mm, 100 mm, and 150 mm

The wide selection of dimensions enables straightforward method transfer between UHPLC and conventional HPLC systems while maintaining excellent chromatographic performance, reproducibility, and robustness.

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