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Ideal Applications

The Restek Raptor C18 stationary phase is an excellent first-choice column for laboratories requiring a versatile reversed-phase solution across a wide range of industries and analytical methods.

Typical applications include:

  • Pharmaceutical active pharmaceutical ingredients (APIs)
  • Pharmaceutical impurities and degradation products
  • Stability-indicating methods
  • Quality control testing
  • Drug metabolites
  • Clinical and bioanalytical assays
  • Veterinary drug residue analysis
  • Food contaminants
  • Pesticide multi-residue methods
  • Mycotoxins
  • Environmental pollutants
  • Industrial chemicals
  • Natural products
  • Cosmetics testing
  • Forensic toxicology

The balanced selectivity of the Raptor C18 makes it particularly suitable for routine analytical methods where reproducibility, robustness, and broad analyte compatibility are essential.

Technical Specifications

Specification Description
Stationary Phase High-purity C18 (Octadecylsilane, ODS)
Particle Technology Superficially Porous (Core-Shell) Silica
Particle Size 2.7 µm
Pore Size 90 Å
USP Classification L1
Surface Chemistry Fully bonded, endcapped C18 phase
Separation Mechanism Reversed-phase hydrophobic interactions
Recommended pH Range 2.0–8.0
Maximum Operating Pressure Compatible with HPLC and UHPLC systems (instrument dependent)
Mobile Phase Compatibility Water, methanol, acetonitrile, phosphate buffers, ammonium formate, ammonium acetate, formic acid, and other LC-MS compatible mobile phases
LC-MS Compatibility Excellent using volatile mobile phases
Available Column Dimensions Multiple analytical and UHPLC formats available

Why Choose the Raptor™ C18 90 Å?

The Restek Raptor C18 90 Å combines the versatility of a traditional C18 stationary phase with the performance advantages of modern core-shell particle technology. The result is a highly efficient column that delivers excellent resolution, consistent retention times, and superior peak shapes while maintaining compatibility with both conventional HPLC and UHPLC instrumentation.

Its robust chemistry supports reliable method development, straightforward method transfer, and high-throughput routine analysis across a broad range of analytical disciplines. Whether analyzing pharmaceuticals, environmental contaminants, food samples, or clinical specimens, the Raptor C18 provides dependable performance and long column lifetime.

Available Column Dimensions

The Restek Raptor C18 90 Å HPLC series is available in multiple dimensions to support method development, routine analysis, and high-throughput laboratories.

  • Particle Size: 2.7 µm
  • Pore Size: 90 Å
  • Internal Diameters: 2.1 mm, 3.0 mm, and 4.6 mm
  • Column Lengths: 30 mm, 50 mm, 100 mm, and 150 mm

This comprehensive range of dimensions enables seamless method scaling between UHPLC and conventional HPLC systems while maintaining chromatographic efficiency and reproducibility.

These advantages allow laboratories to increase sample throughput while maintaining the sensitivity, precision, and robustness required for demanding analytical applications.

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