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High-Precision Inline Flow Monitoring for HPLC, UHPLC, Microfluidics and Process Applications
Continuous High-Resolution Inline Flow Measurement without Interrupting Your Process
Accurate flow control is one of the most critical parameters in liquid chromatography, microfluidics and laboratory fluid handling. Even small deviations in flow rate can affect retention times, quantitative accuracy, reproducibility and overall analytical performance.
Biotech Liquid Flow Meters provide continuous, real-time inline monitoring of liquid flow without disrupting the fluid path. Utilizing advanced thermal heat-dispersion technology, these instruments deliver exceptionally high temporal resolution, enabling users to detect flow instability, pump pulsation and subtle performance variations that conventional volumetric flow measurement methods often fail to identify.
Designed for research laboratories, pharmaceutical quality control, analytical chemistry and industrial process monitoring, the Biotech Flow Meter series combines outstanding measurement accuracy, minimal dead volume and intuitive software into a compact, plug-and-play solution.
Key Advantages
- Continuous real-time flow measurement
- High-resolution thermal flow sensing
- No moving mechanical components
- Extremely low internal volume
- Minimal pressure drop
Find more information in the Biotech Flowmeter Brochure.
You can find instructions in the Biotech Flow Meter Manual.
For more technical details, see the Biotech Flowmeter Tech Notes.
Art.-Nr.: BT-AB-40008
Will be procured as soon as possible
Art.-Nr.: BT-AB-40010
Will be procured as soon as possible
Art.-Nr.: BT-AB-40040
Will be procured as soon as possible
Art.-Nr.: BT-AB-40650
Will be procured as soon as possible
Additional Key Advantages
- Inline measurement without disturbing the flow path
- USB-powered plug-and-play operation
- High-resolution OLED display
- Automatic digital data logging
- Compatible with HPLC, UHPLC, GPC and microfluidic systems
- Multiple solvent calibration factors included
- Compact and portable design
Why Choose Biotech Liquid Flow Meters?
Unlike conventional flow measurement systems that rely on manual collection or volumetric determination, Biotech Liquid Flow Meters continuously record actual flow profiles throughout an experiment.
The innovative sensor design measures flow inside a low-volume flow cell without introducing moving parts or disturbing the liquid stream. This allows precise characterization of pump performance while maintaining the integrity of sensitive chromatographic systems.
Advanced Flow Diagnostics
Flow rate alone rarely tells the complete story.
The Biotech Liquid Flow Meter records complete time-resolved flow profiles, allowing users to visualize:
- Pump pulsation
- Flow instability
- Pressure-related fluctuations
- Check valve malfunction
- Pump seal wear
- Gradient inconsistencies
- Flow drift over time
Because sampling intervals can be selected according to the application, users may monitor average flow behaviour or capture extremely fast transient events that would otherwise remain undetected. This makes the instrument a valuable diagnostic tool for troubleshooting LC pumps and validating chromatographic systems.
Ideal for Chromatography Validation
Modern pharmaceutical laboratories require documented evidence that chromatography systems consistently perform within specification.
Biotech Liquid Flow Meters support:
- IQ (Installation Qualification)
- OQ (Operational Qualification)
- PQ (Performance Qualification)
- Pump performance verification
- Flow accuracy validation
- Instrument qualification
- Preventive maintenance
Each instrument is supplied with a Certificate of Conformity based on a multi-point verification procedure. For regulated environments, an optional traceable 10-point calibration certificate and pump validation protocol are available to simplify compliance and documentation.
Integration with Chromatography Data Systems (CDS)
A unique advantage of the Biotech Liquid Flow Meter is its ability to integrate directly with leading Chromatography Data Systems.
Using the optional CDS connectivity driver, measured flow profiles can be recorded alongside chromatographic data, providing complete documentation of the actual flow conditions during every analysis.
Supported platforms include systems such as:
- Agilent OpenLab
- Waters Empower
- Shimadzu LabSolutions
- Clarity
- WinGPC
- Other RC.Net / ICF compatible chromatography software
This integration enables laboratories to maintain complete analytical traceability while improving confidence in system performance.
Applications
Biotech Liquid Flow Meters are suitable for a wide range of laboratory and industrial applications, including:
Liquid Chromatography
- HPLC
- UHPLC
- Nano-LC
- Capillary LC
- GPC
- SEC
Microfluidics
- Lab-on-chip devices
- Flow chemistry
- Capillary systems
- Nanofluidics
- Microreactors
Process Monitoring
- Continuous manufacturing
- Flow chemistry optimization
- Laboratory automation
- Chemical process control
Instrument Diagnostics
- Pump troubleshooting
- Flow verification
- Preventive maintenance
- Quality assurance
- Method validation
Four Models Cover Nearly Every Flow Range
The Biotech Liquid Flow Meter family offers dedicated instruments for applications ranging from nano-flow chromatography to preparative processing.
| Model | Flow Range | Typical Applications |
|---|---|---|
| Micro Flow Meter | 10 nL/min – 80 µL/min | Nano LC, capillary LC, microfluidics |
| HPLC Flow Meter | 10 µL/min – 5 mL/min | Analytical HPLC, UHPLC, GPC |
| Prep Flow Meter | 0.1 – 40 mL/min | Preparative chromatography |
| High Flow Meter | 0.1 – 650 mL/min | Process monitoring, industrial fluidics |
Technical Specifications
General Specifications
- Measurement principle: Thermal heat-dispersion sensing
- Accuracy: < 0.2% FSD
- Precision: < 0.2% FSD (Micro Flow: < 0.5% FSD)
- Integration times: 78 ms to 9844 ms (application dependent)
- Operating pH range: 1–11
- USB-C powered
- Integrated OLED display
- PC software included
- Continuous data logging
- Compact dimensions: 44 × 71 × 25 mm
- Weight: approximately 54 g
Sensor Materials
Micro Flow & HPLC Models
- Quartz glass (borosilicate)
- PEEK
Preparative & High Flow Models
- PPS
- Stainless Steel 316
- Epoxy resin
The analytical models feature exceptionally low dead volume and very low pressure drop, making them particularly suitable for high-performance chromatographic applications.
Built for Modern Analytical Laboratories
Whether validating an LC system, troubleshooting pump performance or monitoring sensitive microfluidic processes, Biotech Liquid Flow Meters provide precise, continuous and traceable flow measurement with minimal system impact.
The combination of high measurement accuracy, excellent temporal resolution, software-based documentation and seamless CDS integration makes these instruments an ideal solution for laboratories requiring reliable flow verification and comprehensive process insight.
Why Laboratories Choose Biotech Liquid Flow Meters
- Continuous inline measurement without interrupting the flow path
- High-resolution thermal sensing technology
- Flow ranges from 10 nL/min to 650 mL/min
- Extremely low dead volume and pressure drop
- Real-time pump diagnostics and pulsation analysis
- High accuracy and repeatability
- Ready for IQ, OQ and PQ qualification workflows
- USB-powered with intuitive software
- CDS integration for complete analytical documentation
- Suitable for HPLC, UHPLC, GPC, nano-LC, microfluidics and process control