Optimized for Alcohol Biomarker Analysis

EtG and EtS analysis is routinely performed in clinical, forensic, workplace, and toxicology laboratories where analytical reliability is essential. Conventional reversed-phase columns often exhibit insufficient retention of these highly polar analytes, resulting in matrix interferences, poor peak shape, and compromised sensitivity. The Raptor EtG/EtS column overcomes these limitations through a proprietary stationary phase that provides enhanced retention and superior separation of EtG and EtS from endogenous matrix components.

High-Performance LC-MS/MS Method

The Raptor EtG/EtS column supports a rapid dilute-and-shoot workflow, allowing direct analysis of urine samples with minimal sample preparation. Combined with a fast LC gradient, complete chromatographic separation can be achieved in approximately 4 minutes, making the method ideally suited for high-throughput laboratories without sacrificing analytical performance.

Reliable Results in Complex Matrices

The proprietary stationary phase, based on 2.7 µm superficially porous (core-shell) particles, provides excellent chromatographic efficiency while maintaining moderate operating pressures compatible with both HPLC and UHPLC systems. Strong analyte retention minimizes co-eluting matrix compounds, resulting in improved accuracy, lower detection limits, and enhanced confidence in quantitative results.

Designed for Routine Laboratories

The Raptor EtG/EtS column has been developed specifically for laboratories performing routine alcohol biomarker testing. Its rugged stationary phase demonstrates excellent reproducibility and long column lifetime, maintaining consistent chromatographic performance over extended analytical sequences. This durability reduces downtime, minimizes column replacement costs, and ensures reliable day-to-day operation in demanding laboratory environments.

Whether implementing a new LC-MS/MS method or improving an existing workflow, the Restek Raptor® EtG/EtS 2.7 µm column provides the selectivity, robustness, and speed required for confident alcohol biomarker analysis in routine laboratories.