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AdvanceBio RP-mAb Series
AdvanceBio RP-mAb Series LC Columns

Agilent AdvanceBio RP-mAb Columns

Agilent AdvanceBio RP-mAb columns are reversed-phase columns developed for the analysis of intact and reduced monoclonal antibodies (mAbs). They are designed for therapeutic protein characterization in biopharmaceutical discovery, development and QA/QC applications, including the evaluation of changes and microheterogeneity associated with monoclonal antibodies.

AdvanceBio RP-mAb columns are based on Agilent Poroshell technology and use 3.5 µm superficially porous particles with a 450 Å pore size. The wide-pore particles are designed for large biomolecules and provide high-resolution separations with shorter analysis times compared with fully porous particles of the same size. The columns can also be applied in LC/MS methods for chromatographic separation and accurate mass determination of intact mAbs.

Three different bonded-phase chemistries are available: SB-C8, C4 and Diphenyl. These stationary phases provide different selectivities for method development and the characterization of therapeutic proteins, including monoclonal antibodies and antibody drug conjugates (ADCs).

Key Features of AdvanceBio RP-mAb Columns

  • Designed for reversed-phase analysis of intact and reduced monoclonal antibodies (mAbs)
  • 3.5 µm superficially porous particles with 450 Å pore size for large biomolecule separations
  • Available with SB-C8, C4 and Diphenyl chemistries to support flexible method development
  • Suitable for LC/MS analysis and intact mAb mass determination
  • Biopharmaceutical discovery, development and QA/QC applications
  • Robust Poroshell packed bed for extended column lifetime
  • 2 µm inlet frit helps reduce inlet blockage

Use the product filters below to select the appropriate Agilent AdvanceBio RP-mAb column according to stationary phase chemistry, column dimensions and mAb analysis requirements.

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20 Products
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Product Number Description Price Specifications
AT-783775-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 2.1 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-783775-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 150 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-783975-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 4.6 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-783975-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 150 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-785775-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 2.1 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-785775-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 100 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-785975-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 4.6 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-785975-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 100 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-789775-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 2.1 x 50mm, ea.
EUR 919.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-789775-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 50 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 919.00

Will be procured as soon as possible

AT-789975-906 AdvanceBio RP-mAb SB-C8 450Å 3.5µm, 4.6 x 50mm, ea.
EUR 913.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-789975-906
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C8
  • Selectivity Manufacturer: SB-C8
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: no
  • Column Length: 50 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L7
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Bonding Type: monomeric
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 913.00

Will be procured as soon as possible

AT-793775-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 2.1 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-793775-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-793775-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 2.1 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-793775-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-793975-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 4.6 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-793975-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-793975-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 4.6 x 150mm, ea.
EUR 1,269.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-793975-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,269.00

Will be procured as soon as possible

AT-795775-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 2.1 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-795775-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-795775-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 2.1 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-795775-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-795975-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 4.6 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-795975-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-795975-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 4.6 x 100mm, ea.
EUR 1,165.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-795975-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,165.00

Will be procured as soon as possible

AT-797775-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 2.1 x 75mm, ea.
EUR 1,044.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-797775-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 75 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,044.00

Will be procured as soon as possible

AT-797775-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 2.1 x 75mm, ea.
EUR 1,044.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-797775-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 75 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 1,044.00

Will be procured as soon as possible

AT-799775-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 2.1 x 50mm, ea.
EUR 919.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-799775-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 919.00

Will be procured as soon as possible

AT-799775-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 2.1 x 50mm, ea.
EUR 919.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-799775-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 919.00

Will be procured as soon as possible

AT-799975-904 AdvanceBio RP-mAb C4 450Å 3.5µm, 4.6 x 50mm, ea.
EUR 913.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-799975-904
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: C4
  • Selectivity Manufacturer: RP-mAb C4
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L26
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 913.00

Will be procured as soon as possible

AT-799975-944 AdvanceBio RP-mAb Diphenyl 450Å 3.5µm, 4.6 x 50mm, ea.
EUR 913.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-799975-944
  • Manufacturer: Agilent
  • Brand: AdvanceBio RP-mAb
  • Selectivity: Phenyl
  • Selectivity Manufacturer: Diphenyl
  • Particle Size: 3.5 µm
  • Pore Size: 450 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Monoclonal Antibodies (mABs)
  • USP Code: L11
  • Temperature Range: 90 °C
  • pH Range: 1-8
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Package Size: 1

Questions about the article Questions about the article To the product details To the product details

Price:
EUR 913.00

Will be procured as soon as possible

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