Restek Raptor™ HILIC-Si 90 Å HPLC Columns

High-Performance HILIC Separations for Highly Polar Compounds

The Restek Raptor™ HILIC-Si 90 Å HPLC column series is specifically designed for the efficient separation of highly polar compounds that are often poorly retained on conventional reversed-phase columns. Utilizing a bare silica (HILIC-Si) stationary phase combined with Restek's advanced 2.7 µm superficially porous (core-shell) particle technology, these columns deliver exceptional efficiency, sharp peak shapes, and robust reproducibility for demanding analytical applications.

The hydrophilic interaction chromatography (HILIC) retention mechanism provides strong retention for small polar molecules while maintaining excellent compatibility with LC-MS/MS workflows. High organic mobile phase compositions not only improve analyte retention but also enhance electrospray ionization efficiency, making the Raptor HILIC-Si an ideal choice for trace-level quantitative analysis.

Designed for both conventional HPLC and UHPLC systems, the Raptor HILIC-Si 90 Å combines fast mass transfer with moderate backpressure, enabling high-throughput analyses without compromising chromatographic performance.

Key Benefits

• Bare silica stationary phase optimized for Hydrophilic Interaction Liquid Chromatography (HILIC).
• Excellent retention of highly polar compounds that exhibit little or no retention on reversed-phase columns.
• Superior chromatographic efficiency through 2.7 µm superficially porous (core-shell) particles.
• Outstanding peak symmetry for small polar molecules.
• High organic mobile phases improve LC-MS/MS sensitivity by enhancing electrospray ionization.
• Fast equilibration and excellent batch-to-batch reproducibility.
• Compatible with both isocratic and gradient HILIC methods.
• Fully compatible with HPLC, UHPLC, and LC-MS/MS instrumentation.
• Robust performance for routine analysis and method development.

Find more information in the Restek Raptor HILIC-Si Brochure.