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Typical Applications

The Raptor Biphenyl stationary phase is particularly advantageous whenever additional aromatic selectivity is required beyond the capabilities of conventional C18 columns.

Typical applications include:

  • Pharmaceutical active ingredients (APIs)
  • Pharmaceutical impurities and degradation products
  • Stability-indicating methods
  • Positional, structural, and stereoisomer separations
  • Veterinary drug residue analysis
  • Pesticide multi-residue methods
  • Polycyclic aromatic hydrocarbons (PAHs)
  • Phenolic compounds
  • Flavonoids and other natural products
  • Mycotoxins
  • Clinical and forensic toxicology
  • Environmental contaminants
  • Food safety testing

Its unique selectivity frequently allows baseline separation of analytes that co-elute on standard C18 columns, reducing the need for complex gradient optimization or alternative chromatographic methods.

Technical Specifications

Specification Description
Stationary Phase Proprietary Biphenyl bonded phase
Particle Technology Superficially Porous (Core-Shell) Silica
Particle Size 2.7 µm
Pore Size 90 Å
Carbon Load Optimized for balanced hydrophobic and aromatic selectivity
Separation Mechanism Hydrophobic interactions, π-π interactions, dipole interactions, steric (shape) selectivity
USP Classification L11
Recommended pH Range 2.0–8.0
Maximum Operating Pressure Suitable for UHPLC and HPLC systems (instrument dependent)
Mobile Phase Compatibility Water, methanol, acetonitrile, buffered mobile phases, LC-MS compatible solvents
Available Column Dimensions Multiple analytical and UHPLC formats available

Why Choose Raptor™ Biphenyl?

The Raptor Biphenyl 90 Å series provides an ideal balance of efficiency, selectivity, and robustness for laboratories that routinely analyze aromatic compounds. The combination of a highly selective biphenyl ligand with advanced core-shell particle technology enables faster method development, shorter analysis times, and improved chromatographic resolution without compromising system compatibility.

Whether applied in pharmaceutical research, environmental monitoring, food safety, forensic science, or clinical analysis, the Restek Raptor™ Biphenyl 90 Å consistently delivers superior performance for challenging aromatic separations.

Available Column Dimensions

The Raptor Biphenyl 90 Å series is available in a wide range of dimensions to support method development, routine analysis, and high-throughput workflows.

  • Lengths: 30, 50, 100 and 150 mm
  • Internal Diameters:2.1, 3.0 and 4.6 mm
  • Particle Size: 2.7 µm
  • Pore Size: 90 Å

This broad selection allows straightforward method transfer between UHPLC and conventional HPLC systems while maintaining chromatographic performance and analytical robustness.

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