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AdvanceBio Oligonucleotide Series
AdvanceBio Oligonucleotide Series LC Columns

Agilent AdvanceBio Oligonucleotide Columns

Agilent AdvanceBio Oligonucleotide columns provide an ion-pair reversed-phase (IP-RP) chromatography platform for the analytical characterization and purification of oligonucleotides. The stationary phase is designed for the separation of trityl-off, deprotected oligonucleotides and closely related impurities. High-pH and elevated-temperature stability allow separations under denaturing conditions to improve resolution and peak shape.

AdvanceBio Oligonucleotide columns use high-efficiency 2.7 µm and 4 µm superficially porous Poroshell particles with a 120 Å pore size. The silica particles are chemically modified for resistance to high-pH mobile phases and bonded with an end-capped C18 stationary phase that provides selectivity for oligonucleotide separations.

The same particle chemistry is available across different column dimensions, providing a scalable IP-RP platform from analytical separations to preparative purification. Column configurations extend up to 21.2 mm ID preparative columns. The 2.7 µm Poroshell particles are suitable for HPLC and UHPLC systems, while 4 µm Poroshell particles are also available for preparative applications.

Key Features of AdvanceBio Oligonucleotide Columns

  • Ion-pair reversed-phase (IP-RP) chromatography for oligonucleotide analysis and purification
  • 2.7 µm and 4 µm superficially porous Poroshell particles with 120 Å pore size
  • End-capped C18 stationary phase for oligonucleotide selectivity
  • Chemically modified silica with high-pH resistance of pH 3-11
  • Temperature stability up to 65 °C
  • Scalable chemistry from analytical columns to 21.2 mm ID preparative columns
  • Each batch of media is tested with a resolution standard for consistent performance

Use the product filters below to select the appropriate Agilent AdvanceBio Oligonucleotide column according to particle size, column dimensions and analytical or preparative application.

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21 Products
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Product Number Description Price Specifications
AT-653750-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 2.1 x 150mm, ea.
EUR 1,394.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-653750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,394.00

Will be procured as soon as possible

AT-653950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 4.6 x 150mm, ea.
EUR 1,394.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-653950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,394.00

Will be procured as soon as possible

AT-655750-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 2.1 x 100mm, ea.
EUR 1,225.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-655750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,225.00

Will be procured as soon as possible

AT-655950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 4.6 x 100mm, ea.
EUR 1,225.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-655950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,225.00

Will be procured as soon as possible

AT-659750-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 2.1 x 50mm, ea.
EUR 997.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-659750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 997.00

Will be procured as soon as possible

AT-659950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 4.6 x 50mm, ea.
EUR 997.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-659950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 997.00

Will be procured as soon as possible

AT-671050-702 AdvanceBio Oligonucleotide 120Å 4µm, 21.2 x 50mm, ea.
EUR 2,813.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-671050-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 21.2 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 2,813.00

Will be procured as soon as possible

AT-671150-702 AdvanceBio Oligonucleotide 120Å 4µm, 21.2 x 150mm, ea. Price on request
Agilent Technologies
  • Product Number: AT-671150-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 21.2 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price on request
AT-693971-702 AdvanceBio Oligonucleotide 120Å 4µm, 4.6 x 150mm, ea.
EUR 1,160.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-693971-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,160.00

Will be procured as soon as possible

AT-695971-702 AdvanceBio Oligonucleotide 120Å 4µm, 4.6 x 100mm, ea.
EUR 954.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-695971-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 954.00

Will be procured as soon as possible

AT-699971-702 AdvanceBio Oligonucleotide 120Å 4µm, 4.6 x 50mm, ea.
EUR 790.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-699971-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Analytical Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 790.00

Will be procured as soon as possible

AT-820750-921 AdvanceBio Oligonucleotide 120Å 2.7µm, 4.6 x 5mm Fast Guard, pk.3
EUR 878.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-820750-921
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 5 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Direct Connect Guard
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Accessories: Direct Connect Guard
  • Package Size: 3

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Price:
EUR 878.00

Will be procured as soon as possible

AT-820750-941 AdvanceBio Oligonucleotide 120Å 4µm, 4.6 x 5mm Fast Guard, pk.3
EUR 860.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-820750-941
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 5 mm
  • Column ID: 4.6 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Direct Connect Guard
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Accessories: Direct Connect Guard
  • Package Size: 3

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Price:
EUR 860.00

Will be procured as soon as possible

AT-821725-921 AdvanceBio Oligonucleotide 120Å 2.7µm, 2.1 x 5mm Fast Guard, pk.3
EUR 857.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-821725-921
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 5 mm
  • Column ID: 2.1 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Direct Connect Guard
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Accessories: Direct Connect Guard
  • Package Size: 3

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Price:
EUR 857.00

Will be procured as soon as possible

AT-633750-702 AdvanceBio Oligonucleotide 120Å 4µm, 10.0 x 150mm, ea.
EUR 2,501.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-633750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 2,501.00

Will be procured as soon as possible

AT-633950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 10.0 x 150mm, ea.
EUR 2,858.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-633950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 150 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 2,858.00

Will be procured as soon as possible

AT-635750-702 AdvanceBio Oligonucleotide 120Å 4µm, 10.0 x 100mm, ea.
EUR 2,046.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-635750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 2,046.00

Will be procured as soon as possible

AT-635950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 10.0 x 100mm, ea.
EUR 2,343.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-635950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 2,343.00

Will be procured as soon as possible

AT-639750-702 AdvanceBio Oligonucleotide 120Å 4µm, 10.0 x 50mm, ea.
EUR 1,678.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-639750-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,678.00

Will be procured as soon as possible

AT-639950-702 AdvanceBio Oligonucleotide 120Å 2.7µm, 10.0 x 50mm, ea.
EUR 1,921.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-639950-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 2.7 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 50 mm
  • Column ID: 10.0 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 1,921.00

Will be procured as soon as possible

AT-671100-702 AdvanceBio Oligonucleotide 120Å 4µm, 21.2 x 100mm, ea.
EUR 3,357.00

Will be procured as soon as possible

Agilent Technologies
  • Product Number: AT-671100-702
  • Manufacturer: Agilent
  • Brand: AdvanceBio Oligonucleotide
  • Selectivity: C18
  • Selectivity Manufacturer: Oligonucleotide
  • Particle Size: 4.0 µm
  • Pore Size: 120 Å
  • Endcapping: yes
  • Column Length: 100 mm
  • Column ID: 21.2 mm
  • Hardware Material: Stainless Steel
  • Hardware Type: Preparative Column
  • Application: Oligonucleotide
  • USP Code: L1
  • Temperature Range: 65 °C
  • pH Range: 3-11
  • Particle: Silica
  • Particle Shape: Spherical
  • Particle Type: Core-Shell
  • Surface Area: 130 m2/g
  • Bonding Type: monomeric
  • Package Size: 1

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Price:
EUR 3,357.00

Will be procured as soon as possible

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