Agilent AdvanceBio HPLC Columns for Biopharmaceutical Analysis

Agilent AdvanceBio Series

Agilent AdvanceBio HPLC Columns for Biopharmaceutical Analysis

Agilent AdvanceBio HPLC columns are designed for the characterization and quality control of biotherapeutics. The column portfolio covers different chromatographic separation modes for monitoring critical quality attributes (CQAs) of complex biomolecules, including proteins, monoclonal antibodies, peptides and oligonucleotides.

AdvanceBio Column Types and Applications

AdvanceBio SEC: Size exclusion chromatography for aggregate and fragment analysis of proteins and monoclonal antibodies (mAbs). Hydrophilic surface chemistry minimizes nonspecific interactions and supports good peak shape and sample recovery.
AdvanceBio RP-mAb and Peptide Mapping: Reversed-phase chromatography for intact proteins, protein subunits and peptide mapping. These columns support analysis of amino acid sequences and post-translational modifications (PTMs). AdvanceBio Peptide Plus uses a modified charged surface for peptide separations with MS-compatible mobile phases such as formic acid.
AdvanceBio Glycan: Amide-HILIC columns for rapid and reproducible separation and identification of released N-glycans. The columns can be combined with appropriate glycan standards and assignment tools.
AdvanceBio Oligonucleotide: Superficially porous particles with chemically modified surfaces provide high pH and temperature stability for ion-pair reversed-phase analysis and purification of synthetic oligonucleotides, including siRNA and aptamers.
Bio IEX, Bio MAb and AdvanceBio HIC: Ion-exchange chromatography (IEX) and hydrophobic interaction chromatography (HIC) provide separation modes for charge variant analysis and determination of drug-to-antibody ratios (DAR) in antibody drug conjugates (ADCs) under native conditions.
AdvanceBio Surfactant Profiling: Columns for characterization of non-ionic surfactants and their degradation products.

Use the product filters below to select the appropriate Agilent AdvanceBio HPLC column according to chromatographic separation mode, biomolecule type and analytical application.

AdvanceBio Amino Acid Analysis (AAA) Series

AdvanceBio Glycan Mapping Series

AdvanceBio HIC Series

AdvanceBio Oligonucleotide Series

AdvanceBio Peptide Mapping Series

AdvanceBio Peptide Plus Series

AdvanceBio RP-mAb Series

AdvanceBio SEC Series

AdvanceBio Surfactant Profiling Series

Agilent AdvanceBio HPLC Columns for Biopharmaceutical Analysis

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